paper Motamedi M, Lindenthal L, Wagner A, Kemper M, Moneer J, Steichele M, Klimovich A, Wittlieb J, Jenewein M, Böttger A. Hydra Bcl-2 and TMBIMP family proteins display anti-apoptotic functions. Int J Dev Biol 2019, in press.


paper Iachetta R, Ambrosone A, Klimovich A, Wittlieb J, Onorato G, Candeo A, D’andrea C, Intartaglia D, Scotti N, Blasio M, Tino A, Bassi A, Tortiglione C. Real time dynamics of β-catenin expression during Hydra development, regeneration and Wnt signalling activation. Int J Dev Biol 2018; 62(4-5). doi:10.1387/ijdb.180092ct.

paper Klimovich A, Rehm A, Wittlieb J, Herbst E-M, Benavente R, Bosch TCG. Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging 2018; 10(5). doi:10.18632/aging.101440.

paper Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TCG. Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Front Microbiol 2018; 9:629. doi:10.3389/fmicb.2018.00629


paper Augustin R, Schröder K, Murillo Rincón AP, Fraune S, Anton-Erxleben F, Herbst EM, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar TM, Bosch TCG. A secreted antibacterial neuropeptide shapes the microbiome of Hydra. Nat Commun. 2017; Sep26;8(1):698. doi:10.1038/s41467-017-00625-1.

paper Pietschke C, Treitz C, Forêt S, Schultze A, Künzel S, Tholey A, Bosch TCG, Fraune S. Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci U S A. 2017 Oct3;114(40): E8488-E8497. doi:10.1073/pnas.1706879114.


paper Franzenburg S, Walter J, Künzel S, Wang J, Baines JF, Bosch TC, Fraune S. Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39): E3730-8. doi:10.1073/pnas.1304960110.


paper Boehm AM, G Hemmrich, K Khalturin, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, H-H Oberg, and TCG Bosch (2012) FoxO is a critical regulator of stem cell maintenance and immortality in Hydra. Proc Natl Acad Sci USA, 109(48):19697-702

paper Franzenburg S, S Fraune, S Künzel, JF Baines, T Domazet-Lošo, TCG Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. Proc Natl Acad Sci USA 109 (47): 19374-9

paper Hemmrich G, K Khalturin, AM Boehm, M Puchert, F Anton-Erxleben, J Wittlieb, UC Klostermeier, P Rosenstiel, HH Oberg, T Domazet-Lošo, T Sugimoto, H Niwa, and TCG Bosch (2012) Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Mol. Biol. Evol., doi:10.1093/molbev/mss13

paper Boehm AM and TCG Bosch (2012) Migration of multipotent interstitial stem cells in Hydra. Zoology, 2012 Aug 27. [Epub ahead of print] PMID: 22951272 [PubMed – as supplied by publisher]  ScienceDirect


Review Wittlieb J, K Khalturin, TCG Bosch (2010) Transgene Hydra als vielseitiges Modellsystem in “EvoDevo”. Biospektrum 10/2, 186-188.This article was subsequently also included in textbook „Zellbiologie und Mikrobiologie“, Springer Spektrum-Buchpublikation (Ed. Dieter Jahn), 2012.

paper Fraune S, R Augustin, F Anton-Erxleben, Jörg Wittlieb, C Gelhaus, V. B. Klimovich,M. P. Samoilovich, and T.C.G. Bosch (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides Proc. Natl. Acad. Sci. USA , 107,18067-18072 Featured as “Research Highlights” in Nature Immunology (2010) 11, 1083

paper Gee L,  J Hartig, L Law, J Wittlieb, K Khalturin, TCG Bosch, and HR Bode (2010) Beta-catenin plays a central role in setting up the head organizer in hydra. Dev. Biol., 340 (2010) 116–124


paper Milde S, Hemmrich G, Anton-Erxleben F, Khalturin K, Wittlieb J, and TCG Bosch (2009) Characterization of taxonomically-restricted genes in a phylum-restricted cell type. Genome Biol. 10(1):R8